Protein Modification Reagents
Medchemexpress LLC HS-PEG3-CH2CH2NH2 hydrochloride | 2863676-86-0 | 95.0% | 100 MG
HS-PEG3-CH2CH2NH2 hydrochloride is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs utilize two distinct ligands connected by a linker
- Selectively degrades target proteins through the ubiquitin-proteasome system
Medchemexpress LLC Mal-PEG4-propargyl | 1262681-30-0 | MFCD29041878 | 99.7% | C15H21NO6 | 10MG
Mal-PEG4-propargyl is a bifunctional PEG4 linker bearing a maleimide and a propargyl (alkyne) group. It is designed for use in bioconjugation and linker assembly, enabling thiol-maleimide coupling and copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach diverse ligands or linkers.
- Maleimide group enables rapid, selective thiol conjugation.
- Propargyl (alkyne) group supports CuAAC "click" reactions.
- PEG4 spacer improves solubility and reduces steric hindrance.
- Low molecular weight (311.33 g·mol⁻¹) for minimal steric impact.
- High supplied purity (99.7%) for reliable synthetic performance.
Medchemexpress LLC BCN-PEG3-biotin | 1263166-92-2 | 95.0% | 594.76 | C29H46N4O7S | 100 MG
BCN-PEG3-biotin is a click-chemistry linker containing a bicyclononyne (BCN) group, a three-unit polyethylene glycol spacer, and a terminal biotin. It is used for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules and as a biotin tag for affinity capture or detection.
- Facilitates copper-free SPAAC click reactions.
- Three-unit PEG spacer improves solubility and reduces steric hindrance.
- Terminal biotin enables streptavidin-based capture and detection.
- Supplied as an off-white to light yellow solid with ≥95.0% purity.
- Soluble in DMSO (100 mg/mL); powder storage recommended at -20°C.
eMolecules 14-(Amine-PEG3-ethylcarbamoyl)tridecanoic t-butyl ester | Broadpharm |488.710 | C26H52N2O6 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCN | 100mg | 784455746
14-(Amine-PEG3-ethylcarbamoyl)tridecanoic t-butyl ester | Broadpharm |488.710 | C26H52N2O6 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCN | 100mg | 784455746
eMolecules 252378-69-1 | t-Boc-Aminooxy-PEG2-amine | Broadpharm | MFCD29079399 | 264.322 | C11H24N2O5 | 98.000 | CC(C)(C)OC(=O)NOCCOCCOCCN | 1g | 311074480
t-Boc-Aminooxy-PEG2-amine | Broadpharm | 252378-69-1 | MFCD29079399 | 264.322 | C11H24N2O5 | 98.000 | CC(C)(C)OC(=O)NOCCOCCOCCN | 1g | 311074480
eMolecules endo-BCN-PEG8-PFP ester | Broadpharm |783.783 | C36H50F5NO12 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OC[C@@H]2[C@@H]3CCC#CCC[C@H]23)c(F)c1F | 50mg | 798870987
endo-BCN-PEG8-PFP ester | Broadpharm |783.783 | C36H50F5NO12 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OC[C@@H]2[C@@H]3CCC#CCC[C@H]23)c(F)c1F | 50mg | 798870987
Cayman Chemical PEG 2000-dPE 10mg
A PEGylated form of DSPE; has been used in the generation of micelles and in combination with other lipids in the formation of liposomes; liposomes containing DSPE-mPEG(2000) and encapsulating doxorubicin and quercetin reduce tumor growth in an MCF-7/adr multidrug-resistant breast cancer mouse xenograft model
Cayman Chemical BIOnT PROTAC Fragmnt lbrar 5mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 1 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3
Medchemexpress LLC N3-PEG4-C2-NHS ester | 944251-24-5 | 98.9% | 1 G
N3-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). It is a click chemistry reagent containing an azide group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Non-cleavable 4-unit PEG linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Dspe-peg-oh | 99.89% | 100 MG
DSPE-PEG-OH (MW 2000) is a hydroxyl-terminated PEGylated phospholipid. Its hydrophobic tail allows for the encapsulation and aggregation of other hydrophobic drugs, and its hydroxyl terminus is suitable for further reactions. DSPE-PEG-OH (MW 2000) can be used to prepare liposomes or lipid nanoparticles.
- Hydroxyl-terminated PEGylated phospholipid.
- Hydrophobic tail enables encapsulation and aggregation of other hydrophobic drugs.
- Hydroxyl terminus suitable for further reactions.
- Can be used to prepare liposomes or lipid nanoparticles.
Medchemexpress LLC Boc-N-Amido-PEG4-propargyl | 1219810-90-8 | 99.7% | C16H29NO6 | 250 MG
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing an Alkyne group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs themselves are designed with two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets the protein of interest, utilizing the intracellular ubiquitin-proteasome system for selective protein degradation.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Boc-N-Amido-PEG4-propargyl | 1219810-90-8 | 99.73% | C16H29NO6 | 500 MG
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is a click chemistry reagent containing an Alkyne group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that have Azide groups. PROTACs themselves consist of two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, and they degrade target proteins by exploiting the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Degrades target proteins by exploiting the intracellular ubiquitin-proteasome system
Medchemexpress LLC T-Boc-N-amido-PEG15-Br | 3012589-40-8 | 98.0% | C37H74BrNO17 | 100 MG
t-Boc-N-amido-PEG15-Br is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is intended for research use only. PROTACs contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
![eMolecules DSPE-Amide-PEG-Rhodamine, MW 2,000 | Broadpharm |1376.220 | C75H121ClN4NaO13P | 97.000 | [Na+].[Cl-].CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)COCCOCCNC(=O)c1ccccc1-c1c2ccc(cc2oc2cc(ccc12)=[N+](CC)CC)N(CC)CC)OC(=O)CCCCCCCCCCCCCCCCC | 5mg | 795361903](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502472877.JPG-250.jpg)
eMolecules DSPE-Amide-PEG-Rhodamine, MW 2,000 | Broadpharm |1376.220 | C75H121ClN4NaO13P | 97.000 | [Na+].[Cl-].CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)COCCOCCNC(=O)c1ccccc1-c1c2ccc(cc2oc2cc(ccc12)=[N+](CC)CC)N(CC)CC)OC(=O)CCCCCCCCCCCCCCCCC | 5mg | 795361903
DSPE-Amide-PEG-Rhodamine, MW 2,000 | Broadpharm |1376.220 | C75H121ClN4NaO13P | 97.000 | [Na+].[Cl-].CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)COCCOCCNC(=O)c1ccccc1-c1c2ccc(cc2oc2cc(ccc12)=[N+](CC)CC)N(CC)CC)OC(=O)CCCCCCCCCCCCCCCCC | 5mg | 795361903